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Clotting Factors List And Mnemonics For Easy Learning

January 14, 2017 by Dr Hamza Arshad 2 Comments

13 Clotting Factors:

There are main 13 clotting factors that help in the clotting of the blood. This process is also called coagulation. In this process blood changes from liquid to a gel like substance which is called clot. This is a protective mechanism which keeps the blood from loss after injury.

Clotting involves various steps and various pathways. There are main 13  factors but there are some other related substances that also help in clotting and are discussed below:

Absence of any of these  factors results in various diseases, which are listed below in clotting factors table.

13 clotting factors and mnemonics

Clotting Factors Definition:

Clotting factor may be defined as ” the substance or group of substances that help in clot formation (coagulation) is called clotting factor.

Clot formation/ coagulation is not a one step process. There are two different pathways i.e intrinsic and extrinsic pathways of coagulation. All of these factors are involved in different steps of clot formation. And missing of any of these factor causes various clotting diseases such hemophilia.

In order to learn about the diseases and the steps in which each of these factors work, you should read detail below or look at the table.

Clotting Factors Table:

Sr NoFactorAlternate NameFunctionDisorder
1Factor IFibrinogenForm FibrinCongenital Afibrogenmia

And

Familial Renal Amyloidosis
2Factor IIProthrombinTransformed into Thrombin which then activates factor I, V, VII, VIII, XI, XIII, Protein C and plateletsThrombophilia
3Factor IIITissue FactorCo factor of VIIa
4Factor IVCalciumBind Coagulation Factors to phospholipidsNo major effects
5Factor VProaccelerinForms Prothrombinase with factor 10Activated protein C resistance
6Factor VIAccelerin
7Factor VIIStable Factor
OR
Proconvertin
Activates Factor IX & Xcongenital proconvertin deficiency
8Factor VIIIAnti Hemophilic Factor AForms Tenase Complex With Factor 9Haemophilia A
9Factor IXAntihemophilic factor B
OR
Christmas factor
Forms Tenase complex with factor 8 And Activates Factor 10Haemophilia B
10Factor XStuart Prower FactorForms Prothrombinase complex with factor V and converts Prothrombin to thrombinCongenital Factor 10 Deficiency
11Factor XIPlasma Thromboplastin AntecedentActivates Factor 9Haemophilia C
12Factor XIIHageman factor)Activates factor XI, VII and prekallikreinHereditary Angioedema type III
13Factor XIIIFibrin Stabilizing FactorCongenital Factor 13 deficiency
14vWFVon Willebrand factorBinds to Factor 8
And
Mediates platelet adhesion
Von Willebrand disease
15Fletcher factorPrekallikreinActivates XII and prekallikrein; cleaves HMWKPrekallikrein deficiency
Or
Fletcher Factor Deficiency
16HMWKHigh Molecular weight KininogenSupports reciprocal activation of XII, XI, and prekallikreinKininogen deficiency
17FibronectinMediates cell adhesionGomerulopathy with fibronectin deposits
18Antithrombin IIIInhibits IIa, Xa, and other proteasesAntithrombin III deficiency
19Protein CInactivates Va and VIIIaProtein C Deficiency
20Protein SCofactor for activated protein CProtein S deficiency
21Protein ZMediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPIProtein Z deficiency
22PlasminogenConverts to plasmin, lyses fibrin and other proteinsPlasminogen deficiency
23Alpha 2 AntiplasminInhibits plasminAntiplasmin deficiency
24tPATissue plasminogen activatorActivates plasminogenThrombophilia
25UrokinaseActivates plasminogenQuebec platelet disorder
26Cancer procoagulantPathological factor X activationThrombophilia
27PAI1Plasminogen Activator Inhibitor 1Inactivates tPA & urokinasePlasminogen activator inhibitor-1 deficiency
28PAI2Plasminogen Activator Inhibitor 2Inactivates tPA & urokinase

Clotting Factors List:

  • Clotting factor 1: Fibrinogen
  • Clotting factor 2: Prothrombin
  • Clotting factor 3: Tissue Factor Or Tissue Thromboplastin
  • Clotting factor 4: Calcuim
  • Clotting factor 5: Proaccelerain
  • Clotting factor 6: Accelerin or Factor 5a
  • Clotting factor 7: Stable Factor OR Proconvertin
  • Clotting factor 8: Antihemophilic Factor A
  • Clotting factor 9: Christmass Factor OR Antihemophilic Factor B
  • Clotting factor 10: Staurt Prower Factor
  • Clotting factor 11: Plasma Thromboplastin Antecedent
  • Clotting factor 12: Hageman Factor
  • Clotting factor 13: Fibrin Stabilizing Factor
  • vWF Or Von Willebrand factor
  • Prekallikrein (Fletcher factor)
  • High Molecular weight Kininogen or HMWK (Fitzgerald factor)
  • Fibronectin
  • Antithrombin III
  • Protein C
  • Protein S
  • Protein Z
  • Plasminogen
  • Alpha 2 antiplasmin
  • Tissue plasminogen activator or tPA
  • Urokinase
  • Plasminogen Activator Inhibitor 1 (PAI1)
  • Plasminogen Activator Inhibitor 2 Or PAI2
  • Cancer procoagulant

13 Clotting Factors Mnemonics:

There are many mnemoincs for learning 13 clotting factors. I have collected some of the best and shared below:

Fresher’s Party Tonight, Come Let’s Sing And Call Seniors, Please Have Fun

Foolish People Try Climbing Long Slopes After Christmas Some People Have Fallen

Clotting Factors ppt:

If you want a power point presentation to learn each factor in detail or to deliver a presentation, you can do so by downloading a clotting factor ppt below:

Download

Clotting Factors pdf:

We have a pdf guide in which all the clotting factors are discussed in detail. You can download it from here.

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Filed Under: Biochemistry, Physiology Tagged With: 13 clotting factors, blood clotting factor, clotting factors, clotting factors ppt, clotting factors table

About Dr Hamza Arshad

Hamza is the writer and owner of this blog. He is a hobby blogger and student of MBBS in BMC (Bannu Medical college). He blogs to help others and share his knowledge with others.

Comments

  1. Ogah. I. Hannah says

    March 9, 2017 at 9:59 pm

    Thanks so much for sharing your knowledge with us. May God continue to bless you. Pls,can you be my tutor? I’m in school of nursing in Nigeria. All the subjects seems to be too bulking for especially anatomy, foundation of nursing, primary health care, computer etc. I will be expecting your positive reply. Once again, thank you and God bless you

    Reply
    • Admin says

      March 18, 2017 at 7:09 am

      sorry i don’t have time. but i can write on topics for you on this blog.

      Reply

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Hamza is the writer and owner of this blog. He is a hobby blogger and student of MBBS in BMC (Bannu Medical college). He blogs to help others and share his knowledge with others.

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