Clotting Factors List And Mnemonics For Easy Learning

13 Clotting Factors:

There are main 13 clotting factors that help in the clotting of the blood. This process is also called coagulation. In this process blood changes from liquid to a gel like substance which is called clot. This is a protective mechanism which keeps the blood from loss after injury.

Clotting involves various steps and various pathways. There are main 13 factors but there are some other related substances that also help in clotting and are discussed below:

Absence of any of these factors results in various diseases, which are listed below in clotting factors table.

Clotting Factors Definition:

Clotting factor may be defined as ” the substance or group of substances that help in clot formation (coagulation) is called clotting factor.

Clot formation/ coagulation is not a one step process. There are two different pathways i.e intrinsic and extrinsic pathways of coagulation. All of these factors are involved in different steps of clot formation. And missing of any of these factor causes various clotting diseases such hemophilia.

In order to learn about the diseases and the steps in which each of these factors work, you should read detail below or look at the table.

Clotting Factors Table:

Sr No	Factor	Alternate Name	Function	Disorder
1	Factor I	Fibrinogen	Form Fibrin	Congenital Afibrogenmia And Familial Renal Amyloidosis
2	Factor II	Prothrombin	Transformed into Thrombin which then activates factor I, V, VII, VIII, XI, XIII, Protein C and platelets	Thrombophilia
3	Factor III	Tissue Factor	Co factor of VIIa
4	Factor IV	Calcium	Bind Coagulation Factors to phospholipids	No major effects
5	Factor V	Proaccelerin	Forms Prothrombinase with factor 10	Activated protein C resistance
6	Factor VI	Accelerin
7	Factor VII	Stable Factor OR Proconvertin	Activates Factor IX & X	congenital proconvertin deficiency
8	Factor VIII	Anti Hemophilic Factor A	Forms Tenase Complex With Factor 9	Haemophilia A
9	Factor IX	Antihemophilic factor B OR Christmas factor	Forms Tenase complex with factor 8 And Activates Factor 10	Haemophilia B
10	Factor X	Stuart Prower Factor	Forms Prothrombinase complex with factor V and converts Prothrombin to thrombin	Congenital Factor 10 Deficiency
11	Factor XI	Plasma Thromboplastin Antecedent	Activates Factor 9	Haemophilia C
12	Factor XII	Hageman factor)	Activates factor XI, VII and prekallikrein	Hereditary Angioedema type III
13	Factor XIII	Fibrin Stabilizing Factor		Congenital Factor 13 deficiency
14	vWF	Von Willebrand factor	Binds to Factor 8 And Mediates platelet adhesion	Von Willebrand disease
15	Fletcher factor	Prekallikrein	Activates XII and prekallikrein; cleaves HMWK	Prekallikrein deficiency Or Fletcher Factor Deficiency
16	HMWK	High Molecular weight Kininogen	Supports reciprocal activation of XII, XI, and prekallikrein	Kininogen deficiency
17	Fibronectin		Mediates cell adhesion	Gomerulopathy with fibronectin deposits
18	Antithrombin III		Inhibits IIa, Xa, and other proteases	Antithrombin III deficiency
19	Protein C		Inactivates Va and VIIIa	Protein C Deficiency
20	Protein S		Cofactor for activated protein C	Protein S deficiency
21	Protein Z		Mediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPI	Protein Z deficiency
22	Plasminogen		Converts to plasmin, lyses fibrin and other proteins	Plasminogen deficiency
23	Alpha 2 Antiplasmin		Inhibits plasmin	Antiplasmin deficiency
24	tPA	Tissue plasminogen activator	Activates plasminogen	Thrombophilia
25	Urokinase		Activates plasminogen	Quebec platelet disorder
26	Cancer procoagulant		Pathological factor X activation	Thrombophilia
27	PAI1	Plasminogen Activator Inhibitor 1	Inactivates tPA & urokinase	Plasminogen activator inhibitor-1 deficiency
28	PAI2	Plasminogen Activator Inhibitor 2	Inactivates tPA & urokinase